Digital Healthcare Innovation Lab
DHI Lab
The DHI Lab - Digital Healthcare Innovation Lab research group focuses on designing, developing, and validating digital methods and technologies to innovate processes related to prevention, diagnosis, monitoring, and treatment, thereby contributing to a more personalized, predictive, safe, and efficient healthcare system. The group’s activities integrate expertise in medical informatics, artificial intelligence, and data science, with a particular focus on translating research findings into clinical and preclinical applications.
The group works on the integration and analysis of heterogeneous biomedical data—including physiological signals, images, clinical texts, and multimodal data—to develop models and tools to support clinical decision-making. In this context, artificial intelligence is used to create support systems aimed at improving diagnostic accuracy, risk stratification, and the personalization of patient care interventions.
The same expertise is also applied to the development of digital twins of in vitro biological models, used to simulate and predict the response of cellular systems to external stimuli. This approach helps accelerate preclinical research, making experimental evaluation more efficient and helping to reduce time, costs, and the need for animal testing.
Another area of research focuses on smart wearable technologies for remote monitoring, with a particular emphasis on heart failure. The group designs and develops advanced sensors and systems for the continuous, non-invasive acquisition of physiological parameters, with the aim of identifying early signs of clinical deterioration and supporting more timely care models that prioritize continuity of care.
Transversally, the group pays particular attention to the quality, reliability, and transferability of the proposed solutions, addressing the issues of validation, safety, data integrity, and regulatory compliance in an integrated manner within the context of medical device software development.
The group works on the integration and analysis of heterogeneous biomedical data—including physiological signals, images, clinical texts, and multimodal data—to develop models and tools to support clinical decision-making. In this context, artificial intelligence is used to create support systems aimed at improving diagnostic accuracy, risk stratification, and the personalization of patient care interventions.
The same expertise is also applied to the development of digital twins of in vitro biological models, used to simulate and predict the response of cellular systems to external stimuli. This approach helps accelerate preclinical research, making experimental evaluation more efficient and helping to reduce time, costs, and the need for animal testing.
Another area of research focuses on smart wearable technologies for remote monitoring, with a particular emphasis on heart failure. The group designs and develops advanced sensors and systems for the continuous, non-invasive acquisition of physiological parameters, with the aim of identifying early signs of clinical deterioration and supporting more timely care models that prioritize continuity of care.
Transversally, the group pays particular attention to the quality, reliability, and transferability of the proposed solutions, addressing the issues of validation, safety, data integrity, and regulatory compliance in an integrated manner within the context of medical device software development.
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Scientific coordinators
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Research team
Research area
Research topics
- Development and Validation of Medical Device Software (MDS): The goal is to create digital solutions that comply with safety standards and regulatory requirements (MDR/AI Act), ensuring the integrity of the data entered and the reliability of the software itself in clinical settings.
- Decision Support Systems and Heterogeneous Data Mining: the focus is on transforming large volumes of heterogeneous clinical data (data, signals, images, text, etc.) into actionable knowledge to be integrated into Clinical Decision Support Systems (CDSS) capable of supporting healthcare personnel throughout all phases of patient care&cure, improving diagnostic accuracy and the personalization of care.
- AI for In Vitro Device Digital Twins: the goal is to use AI methods to develop digital twins of in vitro biological models capable of simulating and predicting cellular responses to external stimuli, accelerating preclinical testing and drastically reducing the time, costs, and need for traditional animal testing.
- Smart Wearable Technologies for Remote Monitoring of Heart Failure: This research focuses on developing next-generation wearable sensors for the continuous, non-invasive monitoring of patients with heart failure, with the aim of identifying early signs of clinical deterioration, facilitating discharge from the hospital, and optimizing remote patient management to achieve more efficient community medicine.
Skills
ERC sectors
SDG
Keywords
Research collaborations
Pubblicazioni da archivio istituzionale
Publications from the institutional repository
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Introvaia, Alessandra; Giordano, Noemi; Rosati, Samanta; Cannone, Silvia; Baima, ... (2026)
Data Warehouse to Support Clinical Trials in Dentistry. In: EFMI MIE 2026, Genova (Ita), 25-28 Maggio 2026, pp. 1569-1570. ISSN 0926-9630. ISBN: 9781643686615 -
Introvaia, Alessandra; Ruocco, Gerardina; Nicoletti, Letizia; Rosati, Samanta; Chiono, ... (2026)
Integrating Radiomics and Machine Learning to Improve Fluorescence Image Segmentation in in vitro models. In: EFMI MIE 2026, Genova (Ita), 25-28 May 2026, pp. 143-147. ISSN 0926-9630. ISBN: 9781643686615 -
Giordano, Noemi; Cannone, Silvia; Knaflitz, Marco; Balestra, Gabriella (2025)
Impact of the auscultation area on heart sound waveforms for the estimation of Cardiac Time Intervals. In: 2025 47th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Copenhagen (Den), 14-18 July 2025, pp. 1-7. ISSN 2694-0604. ISBN: 979-8-3315-8618-8 -
Giordano, Noemi; Cannone, Silvia; Balestra, Gabriella; Knaflitz, Marco (2025)
Independence on the lead of the identification of the ventricular depolarization in the electrocardiogram in wearable devices. In: COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE UPDATE, vol. 8. ISSN 2666-9900 -
Introvaia, Alessandra; Bezze, Andrea; Muccio, Sara; Mattu, Clara; Balestra, Gabriella (2025)
Intelligent System for Automated Spheroid Segmentation Using Machine Learning. In: 35th Medical Informatics Europe Conference - MIE 2025, Glasgow (UK), 19–21 May 2025, pp. 557-561. ISSN 0926-9630. ISBN: 9781643685960 -
Cannone, Silvia; Giordano, Noemi; Loforte, Antonio; Spitaleri, Antonio; Gallone, ... (2025)
Pilot study on the separability of the native heart sounds and device support noise in patients implanted with left ventricular assist devices. In: 2025 47th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Copenaghen (Dan), 14-18 July 2025, pp. 1-6. ISSN 2694-0604. ISBN: 979-8-3315-8618-8 -
Panic, Jovana; Defeudis, Arianna; Vassallo, Lorenzo; Cirillo, Stefano; Gatti, Marco; ... (2025)
Rectal Cancer Segmentation: A Methodical Approach for Generalizable Deep Learning in a Multi-Center Setting. In: INTERNATIONAL JOURNAL OF IMAGING SYSTEMS AND TECHNOLOGY, vol. 35. ISSN 0899-9457 -
Murgia, Y.; Gazzarata, R.; Ciampi, M.; Sicuranza, M.; Cirillo, F.; Esposito, C.; Maggi, ... (2025)
The challenges of national health data ecosystems in feeding the European health data space: the Italian example. In: FRONTIERS IN MEDICINE, vol. 12. ISSN 2296-858X -
Cannone, Silvia; Giordano, Noemi; Knaflitz, Marco; Balestra, Gabriella (2025)
Usability-driven design of medical device APPs for telemonitoring of chronic patients. In: 2025 IEEE 13th International Conference on Healthcare Informatics (ICHI), Rende (Ita), 18-21 June 2025, pp. 671-672. ISBN: 979-8-3315-2094-6 -
Panic, J.; Defeudis, A.; Vassallo, L.; Cirillo, S.; Gatti, M.; Esposito, A.; ... (2024)
A Fully Automatic Multi-Vendor AI-System To Segment And Predict Resistance To Treatment Of Rectal Cancer On MRI. In: 10th World Congress on New Technologies, NewTech 2024, Barcelona (Spa), August 25-27, 2024. ISSN 2369-8128 -
Giordano, Noemi; Sbrollini, Agnese; Morettini, Micaela; Rosati, Samanta; Balestra, ... (2024)
Acquisition Devices for Fetal Phonocardiography: A Scoping Review. In: BIOENGINEERING, vol. 11. ISSN 2306-5354 -
Introvaia, Alessandra; Muccio, Sara; Bezze, Andrea; Mattu, Clara; Balestra, Gabriella (2024)
Automatic Segmentation of Multicellular Tumour Spheroids Images During Growing. In: European Federation for Medical Informatics Special Topic Conference (EFMI STC) 2024 - Collaboration across Disciplines for the Health of People, Animals and Ecosystems, Timisoara (RO), 27 to 29 November 2024, pp. 230-234. ISSN 0926-9630. ISBN: 9781643685540 -
Scotto, Andrea; Giordano, Noemi; Rosati, Samanta; Balestra, Gabriella (2024)
Design of a Digital Twin of the Heart for the Management of Heart Failure Patients. In: Medical Informatics Europe (MIE) 2024, Athens (Greece), 25-29 August 2024, pp. 875-876. ISSN 0926-9630. ISBN: 9781643685335 -
Sacchi, Lucia; Balestra, Gabriella; Veltri, Pierangelo; Giacomini, Mauro (2024)
Education in Health Informatics: Perspectives from the Italian Society for Biomedical Informatics (SIBIM). In: International Conference on Wearable Micro and Nano Technologies for Personalized Health, Rende (Italy), 27-29 May, 2024, pp. 187-191. ISSN 0926-9630. ISBN: 978-1-64368-518-2 -
Zhang, Yanhua; Balestra, Gabriella; Zhang, Ke; Wang, Jingyu; Rosati, Samanta; Giannini, ... (2024)
MultiTrans: Multi-branch transformer network for medical image segmentation. In: COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE, vol. 254. ISSN 0169-2607 -
Giordano, Noemi; Rosati, Samanta; Fortunato, Daniele; Knaflitz, Marco; Balestra, ... (2024)
Personalized Detection of Motion Artifacts for Telemonitoring Applications. In: pHealth 2024, Rende (Italy), 27-29 May 2024, pp. 155-159. ISSN 0926-9630. ISBN: 9781643685182 -
Giordano, Noemi; Cannone, Silvia; Balestra, Gabriella; Rosati, Samanta; Knaflitz, Marco (2024)
Separation of the Valvular Contribution to Heart Sounds through Blind Source Separation in Multi-Channel Phonocardiography. In: Computing in Cardiology, Karlsruhe (Ger), 08-11 September 2024. ISSN 2325-887X -
Giordano, Noemi; Bolognini, Irene; Knaflitz, Marco; Rosati, Samanta; Balestra, Gabriella (2024)
Stratification of Heart Sounds Morphology Through Unsupervised Learning. In: Medical Informatics Europe (MIE), Athens (Greece), 25-29 August 2024, pp. 889-893. ISSN 0926-9630. ISBN: 9781643685335 -
Giordano, Noemi; Rosati, Samanta; Balestra, Gabriella; Knaflitz, Marco (2023)
A Wearable Multi-Sensor Array Enables the Recording of Heart Sounds in Homecare. In: SENSORS, vol. 23. ISSN 1424-8220 -
Fiandra, C.; Rosati, S.; Arcadipane, F.; Dinapoli, N.; Fato, M.; Franco, P.; Gallio, E.; ... (2023)
Active bone marrow segmentation based on computed tomography imaging in anal cancer patients: A machine-learning-based proof of concept. In: PHYSICA MEDICA, vol. 113. ISSN 1120-1797